Primer On Cushing's Disease

by Webvet

Cushing’s disease, named after the first physician who reported it, is caused by an excess of cortisol in the body.  It is most common in middle-aged to older dogs, especially poodles, dachshunds, Boston terriers, boxers, and beagles.

Cortisol is a corticosteroid hormone that is involved in metabolism and response to stress.  

It is produced by the adrenal glands, which are found on top of the upper part of the kidneys.  The adrenal glands produce cortisol in response to another hormone that is secreted by the pituitary gland.  The pituitary gland, which is found in the brain, is called the master gland because it secretes a number of hormones that act elsewhere in the body, telling other organs to release additional hormones.

A tumor in either the pituitary gland or the adrenal glands can lead to too much cortisol and Cushing’s disease.  

Common signs include excessive water drinking and urinating.  Dogs often develop a “pot-bellied” appearance because cortisol thins the muscles of the abdomen, allowing the belly to sag, as well as increases the size of the liver.  Other common signs include hair loss (symmetrical), skin rash, darkened or thickened skin, weakness, sluggishness, and wounds that don’t heal well.

Diagnosis includes tests to measure blood levels of cortisol under various conditions.  

Because a series of blood samples is needed on a defined schedule (every 1-2 hours), pets usually need to stay in the veterinary hospital for the day.

Treatment is aimed at decreasing the amount of cortisol in the body.  

Medications are available that destroy part of the adrenal gland (and so decrease the production of cortisol), or that counteract the hormone sent out by the pituitary gland to prevent the adrenal glands from producing too much cortisol in the first place.

Cushing’s disease can also develop in dogs that have had to be treated long-term with corticosteroid medications for other problems.  

These medications act the same way that cortisol does, so their side effects include the same signs, ie, drinking a lot of water, urinating frequently, etc.  When corticosteroid medications have been given long-term, they must be discontinued gradually to give the body time to get used to properly regulating its metabolism again.  Your veterinarian will work with you on a program to gradually decrease your pet’s dosage of corticosteroid medication.

  • Drinking a lot of water
  • Urinating more than usual
  • Pot-bellied appearance
  • Hair loss
  • Dark or thickened skin
  • Slow-healing wounds
  • Weakness
  • Sluggishness


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  1. Thank you for this. Our veterinarian thinks Kelly may have Cushing's disease, but so far her only symptom is excessive thirst. We've done some blood work and are keeping an eye on things.

    1. Cushing's is easy to suspect with many problems; with Jasmine's episodes it was making it on the differential repeatedly. Regular blood work doesn't really show much other than elevated liver values. There is a specific test for Cushing's but it is easier to start with urine cortisol:creatinine ratio. Less invasive and if the numbers are off then it warrants further testing. There is Viva's story on my blog, she had Cushing's.

      Those might really be helpful to you, as it is a real-life account.

      Viva Has Cushing's

      Living With a Cushing's Dog

      What's Changed in Treatment and Diagnosis of Cushing's since Viva's Treatment


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