Friday, July 13, 2012

Veterinary Highlights: Intravenous Lipid Emulsion (ILE) As An Antidote For Some Types Of Poisoning

Intravenous lipid emulsion (ILE) is a preparation of microscopic drops of oil that are infused into a patient's bloodstream.

ILE has been reported as an antidote for local anesthetic and other fat soluble drug toxic reactions. 

It is an emerging therapy and it might prove to be a major advance in treatment of fat soluble poisons.

How does it become an antidote isn't completely understood. It is believed that it acts as a sink for fat soluble substances. The toxic compound is captured by the fat which reduces the toxic effect.

Another theory is that the benefit is linked to improvements in cardiac function.

Apparently, this therapy can work very fast.

In my opinion, fast is good for a number of reasons.

This therapy could potentially be effective in treatment of toxic reactions to ivermectin, moxidectin, lidocaine, bupivaciane, propranolol, verapamil, clomipramine, permethrins, and baclofen.

It is a new idea and safety studies are pending. Similar substances have been previously used as a part of intravenous feeding and appear to be safe.

Something to keep on a lookout for.

Source article:
Potential New Treatment for Some Types of Poisonings

Further reading:
A potential new treatment for ivermectin toxicosis, and more
Intravenous lipid emulsion for treatment of local anesthetic toxicity


At July 25, 2012 at 12:25 PM , Anonymous veterinary said...

That is such a good idea and we hope lots of people take advantage of it. We have never seen anything like that advertised around here.


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