Friday, October 30, 2015

Veterinary Highlights: New Treatment of Chemotherapy-Induced Diarrhea in Dogs on the Horizon

In 2016, Jaguar Animal Health is hoping to launch a new drug to control chemotherapy-induced diarrhea in dogs. A formulation for treatment of watery diarrhea from other causes where symptomatic treatment is indicated is also in the pipeline.

The active ingredient is crofelemer, a botanical extract  from the stem bark latex of the Croton lechleri tree.

Croton lechleri tree. Image Wiki Well

Crofelemer has been used in people for management of non-infectious diarrhea in adult patients such as those on antiretroviral therapy. It acts mainly locally within the GI tract. It seems to be well-tolerated because of minimal systemic absorption.

The company completed their study and submitted the data to FDA for approval.

I am not a fan of symptomatic treatments but there is a time and place where they can make a big difference.

Particularly where the cause is knows but cannot be successfully addressed, or with therapy where the benefit might outweigh the side effects particularly if those can be controlled.

I'm sure there are more different ways to deal with side effects of chemotherapy in dogs, such as protocol adjustment and/or holistic support, but this drug might become a handy tool in veterinarian's arsenal.

Source article:
Jaguar Optimistic About Diarrhea Drug

Further reading:
Jaguar Animal Health Product Pipeline

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