Researchers at the University of Pennsylvania and Michigan State University are conducting a study on use of gene therapy to reverse inherited form of color blindness in dogs, achromatopsia (rod monochromacy or total congenital color blindness).
The viral-mediated gene replacement therapy treats day blindness in affected dogs.
So far, the treatment demonstrated functional rescue of cone cells in almost 100% of treated eyes.
Apparently, it is important that the cone cells are not fully degenerated for the treatment to work.
The treatment consists of two phases - first some of the light-sensitive cells are partially destroyed, which then allows for new growth. This is followed by gene therapy to replace the mutated gene.
Very interesting research.
Dogs’ Born Blind Regain Vision
Penn-Michigan State Team Develops Novel Gene Therapy for Achromatopsia
Komáromy Comparative Ophthalmology Laboratory Research