Why only some cancer cells form tumors?
Researchers at the University of Wisconsin-Madison School of Veterinary Medicine (SVM) might have found the answer. Their recent study discovered a connection between increased expression of a particular gene and bone cancer.
There are several hundred genes that express differently in tumor-forming and nontumor-forming cells.
One protein (Frizzled-6), however, was present in substantially higher levels in cells that did form tumors.
This protein involved in communication between the outside and the inside of a cell. When the communication goes awry, it might contribute to tumor development. Whether or not glitch in expression of this protein is solely responsible for tumor formation or it is just one piece of the puzzle remains to be found.
While this discovery will need more research, it might eventually provide another target for therapy.
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