The study employs gene therapy to normalize glial activity to stop neuropathic pain.
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Glial cells are non-neural cells in the nervous system that provide support and electrical insulation between neurons. They also act as central nervous system regulators. They can also excite neurons that transmit pain signals and contribute to chronic neuropathic pain.
The study is testing the effect of Interleukin-10, an anti-inflammatory regulatory protein injections.
The therapy should normalize glial activity, stimulate tissue regeneration and growth, decrease production of pro-inflammatory substances and increase production of anti-inflammatory substances and eliminate pain.
Originally, the study was focused on treating pain from spinal issues. Including joint pain in the study allows larger pool of participating dogs.
September 27, 2013
Update on the study: Eight out of nine dogs included in the study experienced significant pain relief.
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