Friday, February 24, 2012

Veterinary Highlights: New Approved Treatment Of Mast Cell Tumors In Dogs

Mast cell tumors are one of the most common forms of cancer in dogs. At the root of it is the of control proliferation of normal cells in the skin (mast cells).

Tyrosine kinase inhibitors helped revolutionize the management of some human cancers.

Tyrosine kinase is an enzyme involved in regulating cellular functions. Think of it as an off and on switch for cellular division and survival (among other things). In cancer, this enzyme gets stuck in the “on” position, which results in unregulated cell growth. Clever, and often quite effective.

AB Science is bringing this therapy to veterinary medicine.

Kinavet-CA1® is a drug that  has been approved for canine mast cell tumors.

Kinavet-CA1® works in three ways
  • by blocking the survival signal of the tumor cells which may cause disappearance of the tumor
  • by preventing tumor growth
  • by preventing the spread/metastasis of the tumor cells.

Personally I  like to see treatments that can discriminate between healthy and cancerous cells. But the clinical trials with Kinavet-CA1® had good results.

Further reading: Kinavet
Masitinib is safe and effective for the treatment of canine mast cell tumors
Hot Literature: Long-term success for masitinib in dogs with MCTs

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